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Article

Cdh1 controls the stability of TACC3.

Cell cycle (Georgetown, Tex.) - 1 Nov 2009

Jeng Jen-Chong, Lin Ying-Mei, Lin Chiou-Hong, Shih Hsiu-Ming

Abstract excerpt

Transforming acidic coiled-coil protein 3 (TACC3) was reported to be important for regulating mitotic spindle assembly and chromosome segregation. While the protein level of TACC3 was shown to be altered during cell cycle progression, the molecular mechanism in controlling TACC3 level is unclear. Here, we show that TACC3 protein level can be regulated by Cdh1, a well known activator of anaphase-promoting...

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Source

Identifiers

PMID: 19823035
DOI: 10.4161/cc.8.21.9935

Genes

TACC3

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Related research

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Research trail→

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TACC3-TSC2 maintains nuclear envelope structure and controls cell divisionSemantic proximity Read ↗

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Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway.Semantic proximity Read ↗

The Third Member of the Transforming Acidic Coiled Coil-Containing Gene Family, TACC3, Maps in 4p16, Close to Translocation Breakpoints in Multiple Myeloma, and Is Upregulated in Various Cancer Cell LinesSemantic proximity Read ↗

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