Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Localization of Human TACC3 to Mitotic Spindles Is Mediated by Phosphorylation on Ser558 by Aurora A: A Novel Pharmacodynamic Method for Measuring Aurora A Activity

1 Jun 2007

Abstract excerpt

Aurora A is a serine/threonine protein kinase essential for normal mitotic progression. Aberrant increased expression of Aurora A, which occurs frequently in human cancers, results in abnormal mitoses leading to chromosome instability and possibly tumorigenesis. Consequently, Aurora A has received considerable attention as a potential target for anticancer therapeutic intervention. Aurora A coordinates several...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17545617
DOI: 10.1158/0008-5472.can-07-0122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Localization of Human TACC3 to Mitotic Spindles Is Mediated by Phosphorylation on Ser558 by Aurora A: A Novel Pharmacodynamic Method for Measuring Aurora A ActivityPMID 17545617Read ↗

Aurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A ReviewSemantic proximity Read ↗

The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferationSemantic proximity Read ↗

Aurora Kinases: New Targets for Cancer TherapySemantic proximity Read ↗

Aurora-A Kinase as a Promising Therapeutic Target in CancerSemantic proximity Read ↗

An update on the pharmacokinetics and pharmacodynamics of alisertib, a selective Aurora kinase A inhibitorSemantic proximity Read ↗

Aurora B Inhibitors as Cancer TherapeuticsSemantic proximity Read ↗

Aurora kinase inhibitors: Progress towards the clinicSemantic proximity Read ↗

Biology of Aurora A kinase: Implications in cancer manifestation and therapySemantic proximity Read ↗

Aurora Kinases as Anticancer Drug TargetsSemantic proximity Read ↗

A New Aurora in Anaplastic Thyroid Cancer TherapySemantic proximity Read ↗

Aurora Kinase Inhibitors - Rising Stars in Cancer Therapeutics?Semantic proximity Read ↗

Aurora Kinases: Their Role in Cancer and Cellular ProcessesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.