Article

Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases

2024-12-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Alzheimer’s disease (AD), Dementia with Lewy bodies (DLB), and Parkinson’s disease (PD) represent a spectrum of neurodegenerative disorders (NDDs). Here, we performed the first direct comparison of their transcriptomic landscapes. <h4>METHODS</h4> We profiled the whole transcriptomes of NDD cortical tissue by snRNA-seq. We used computational analyses to identify common an...

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Literature Corpus work: aa987017-a59c-5951-9f17-626fcd80ca44
DOI: 10.1101/2024.12.13.628436

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