Article

Glial metabolic states in human sporadic amyotrophic lateral sclerosis uncovered by spatial single-cell proteomics.

2026-03-25

Abstract excerpt

<title>Abstract</title> <p>Sporadic amyotrophic lateral sclerosis (ALS) is characterized by selective motor neuron vulnerability accompanied by prominent glial responses, yet their molecular heterogeneity and spatial organization in the human central nervous system and spinal cord remain incompletely defined. Here, we delineate ALS-associated glial states in situ by spatially resolved, single-cell proteomic profi...

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Literature Corpus work: afb6a83c-c827-5753-bca6-007220e7cea6
DOI: 10.21203/rs.3.rs-9006017/v1

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