Article

Distinct mechanistic pathways of early tauopathy revealed by MAPT mutations

2026-03-12

Abstract excerpt

<title>Abstract</title> <p>Tau pathology underlies a broad spectrum of neurodegenerative disorders, collectively termed tauopathies, yet these diseases exhibit striking heterogeneity in their biological mechanisms and clinical outcomes. The basis for this heterogeneity remains poorly understood. Here, we address this question using knock-in mouse models expressing two distinct frontotemporal dementia-associated t...

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Literature Corpus work: ca4ea19b-437b-5541-bcb9-4a3eb15e63f0
DOI: 10.21203/rs.3.rs-8751712/v1

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