Article

Epigenetic–splicing regulation of <i>hTERT</i> mediated by <i>hTAPAS</i>

2026-05-12

Abstract excerpt

Telomerase activity is primarily controlled by expression of the catalytic subunit hTERT , yet the mechanisms coordinating its transcriptional and post-transcriptional regulation remain incompletely understood. Paradoxically, hypermethylation of a CpG-rich region upstream of the hTERT transcription start site, termed the TERT Hypermethylated Oncological Region (THOR), is strongly associated with hTERT activati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df7d3153-f5de-5f0d-ba8e-d87fe95fc16a
DOI: 10.64898/2026.05.08.723733

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetic–splicing regulation of <i>hTERT</i> mediated by <i>hTAPAS</i>DOI 10.64898/2026.05.08.723733Read

Pervasive promoter hypermethylation of silenced <i>TERT</i> alleles in human cancersSemantic proximity Read

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers.Semantic proximity Read

Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancerSemantic proximity Read

Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines.Semantic proximity Read

Long-Range Chromatin Interactions Drive Mutant TERT Promoter Activation.Semantic proximity Read

Human telomerase reverse transcriptase regulation by DNA methylation, transcription factor binding and alternative splicing (Review)Semantic proximity Read

Apurinic/apyrimidinic endodeoxyribonuclease 2 ( <i>APEX2</i> /APE2) is required for efficient expression of <i>TERT</i> in human embryonic stem cellsSemantic proximity Read

Interplay between <i>TERT</i> promoter mutations and methylation culminates in chromatin accessibility and <i>TERT</i> expressionSemantic proximity Read

Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes.Semantic proximity Read

Alternative splicing is a developmental switch for hTERT expressionSemantic proximity Read

Targeted Long-Read Bisulfite Sequencing Identifies Differences in the TERT Promoter Methylation Profiles between TERT Wild-Type and TERT Mutant Cancer CellsSemantic proximity Read

Diverse regulatory manners of human telomerase reverse transcriptaseSemantic proximity Read