Back to search

Article

Apurinic/apyrimidinic endodeoxyribonuclease 2 ( <i>APEX2</i> /APE2) is required for efficient expression of <i>TERT</i> in human embryonic stem cells

2024-09-23

Abstract excerpt

<h4>ABSTRACT</h4> Human stem cells rely on enhanced DNA repair mechanisms to safeguard their ability to replenish somatic tissues. Telomerase counteracts telomere shortening and is a component of the stem cell DNA repair system that is regulated by ATM and ATR kinases. Here, we report that the DNA repair enzyme APEX2, but not its close paralog APEX1, is required for efficient telomerase reverse transcriptase ( T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
48010ff2-1f0a-5479-9947-006cbeffdc57
DOI
10.1101/2024.09.23.614488
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Apurinic/apyrimidinic endodeoxyribonuclease 2 ( <i>APEX2</i> /APE2) is required for efficient expression of <i>TERT</i> in human embryonic stem cellsDOI 10.1101/2024.09.23.614488
Telomerase RNA regulates the epigenome primed for human lineage commitmentSemantic proximity
Epigenetic–splicing regulation of <i>hTERT</i> mediated by <i>hTAPAS</i>Semantic proximity
Alternative splicing is a developmental switch for hTERT expressionSemantic proximity
Pervasive promoter hypermethylation of silenced <i>TERT</i> alleles in human cancersSemantic proximity
hTERT associates with human telomeres and enhances genomic stability and DNA repairSemantic proximity
Direct RNA sequencing of primary human T cells reveals the impact of immortalization on mRNA pseudouridine modificationsSemantic proximity
Human <i>ribomes</i> reveal DNA-embedded ribonucleotides as a new type of epigenetic markSemantic proximity
Antagonistic H3K79me-H3K9ac crosstalk determines elongation at housekeeping genes to promote pluripotencySemantic proximity
Single cell analysis of lincRNA expression during human blastocyst differentiation identifies <b> <i>TERT</i> <sup> <i>(+)</i> </sup> </b> multi-lineage precursor cellsSemantic proximity
Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomeraseSemantic proximity
A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.Semantic proximity
Two separation-of-function isoforms of human TPP1 and a novel intragenic noncoding RNA dictate telomerase regulation in somatic and germ cellsSemantic proximity
Select a neighboring publication to make it the new centre.