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Diverse regulatory manners of human telomerase reverse transcriptase

11 Jun 2019

Abstract excerpt

Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase and plays important roles in human cancers. Aberrant expression of hTERT is closely associated with tumorigenesis, cancer cell stemness maintaining, cell proliferation, apoptosis inhibition, senescence evasion and metastasis. The molecular basis of hTERT regulation is highly complicated and consists of various layers. A deep...

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PMID: 31186051
DOI: 10.1186/s12964-019-0372-0

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