Article

Integrated Stress Response Signatures Drive Monocyte Dysfunction in <i>GBA1</i>- and <i>LRRK2</i>-Linked Parkinson’s Disease

2025-10-13

Abstract excerpt

Monocytes are increasingly implicated in Parkinson’s disease (PD) pathogenesis, with idiopathic cases showing mitochondrial and lysosomal dysfunction. However, the impact of PD-associated mutations on monocytes remains unclear. To address this, we investigated transcriptomic and functional disturbances in peripheral monocytes from patients with GBA1 - and LRRK2 -associated PD and idiopathic PD. Transcriptomic data...

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Literature Corpus work: df73e0e5-dc6b-5fbc-a86d-1aac4473745e
DOI: 10.1101/2025.10.08.25337448

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