Article

Discordant transcriptional signatures of mitochondrial genes in Parkinson’s disease human myeloid cells

2020-07-22

Abstract excerpt

An increasing number of identified Parkinson’s disease (PD) risk loci contain genes highly expressed in innate immune cells, yet their potential role in pathological mechanisms is not obvious. We have generated transcriptomic profiles of CD14 + monocytes from 230 individuals with sporadic PD and age-matched healthy subjects. We identified dysregulation of genes involved in mitochondrial and proteasomal function....

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Literature Corpus work: db87442f-bf46-55ca-a203-4e0624481b9a
DOI: 10.1101/2020.07.20.212407

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