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Article

Multi-omics insights into GBA1-associated Parkinson's disease: interplay of genomics, transcriptomics, proteomics, and lipidomics.

Molecular neurodegeneration - 29 Jan 2026

Ni Yang, Cai Huaibin, Shao Yaping, Le Weidong

Abstract excerpt

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide. The pathogenesis of PD is driven by multifactorial mechanisms involving a complex interplay among environmental exposures, genetic susceptibility, and aging-related processes. Among genetic contributors, heterozygous pathogenic variants in the GBA1 gene represent the most significant heritable risk factor for PD. The...

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Identifiers

PMID: 41612462
DOI: 10.1186/s13024-026-00931-7
PMCID: PMC12857040

Genes

GBA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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