Article

Transcriptome deregulation of peripheral monocytes in <i>GBA</i>-related Parkinson’s disease

2021-12-24

Abstract excerpt

<h4>Background</h4> Genetic mutations in the beta-glucocerebrosidase (GCase), GBA gene, represent the major genetic risk factor for Parkinson’s disease (PD). The function of the GBA gene is at the crossroads between the endo-lysosomal pathway and the immune response, two important mechanisms involved in the pathogenesis of PD. However, modifiers of GBA penetrance have not yet been fully elucidated. <h4>Methods</h4...

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Literature Corpus work: 6a1e5fa7-43b7-56f5-b2aa-815b89213752
DOI: 10.1101/2021.12.22.21267952

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