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Article

Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease.

Neurobiology of disease - 1 Mar 2014

Mutez Eugénie, Nkiliza Aurore, Belarbi Karim, de Broucker Amélie, Vanbesien-Mailliot Christel, Bleuse Séverine, Duflot Aurélie, Comptdaer Thomas, Semaille Pierre, Blervaque Renaud, Hot David, Leprêtre Frederic, Figeac Martin, Destée Alain, Chartier-Harlin Marie-Christine

Abstract excerpt

The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is a common genetic cause of Parkinson's disease (PD). Although patients with sporadic PD and individuals with LRRK2-linked PD display the classical PD phenotype, it is not known whether or not the same biological pathways are deregulated in each context. By using transcriptome profiling, we investigated the deregulation of various biological pathways in a...

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Identifiers

PMID: 24269915
DOI: 10.1016/j.nbd.2013.11.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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