Transcriptome deregulation of peripheral monocytes and whole blood in GBA-related Parkinson's disease.

doi:10.1186/s13024-022-00554-8

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Article

Transcriptome deregulation of peripheral monocytes and whole blood in GBA-related Parkinson's disease.

Molecular neurodegeneration - 17 Aug 2022

Riboldi Giulietta Maria, Vialle Ricardo A, Navarro Elisa, Udine Evan, de Paiva Lopes Katia, Humphrey Jack, Allan Amanda, Parks Madison, Henderson Brooklyn, Astudillo Kelly, Argyrou Charalambos, Zhuang Maojuan, Sikder Tamjeed, Oriol Narcis J, Kumar Shilpa Dilip, Janssen William, Sowa Allison, Comi Giacomo P, Di Fonzo Alessio, Crary John F, Frucht Steven J, Raj Towfique

Abstract excerpt

BACKGROUND: Genetic mutations in beta-glucocerebrosidase (GBA) represent the major genetic risk factor for Parkinson's disease (PD). GBA participates in both the endo-lysosomal pathway and the immune response, two important mechanisms involved in the pathogenesis of PD. However, modifiers of GBA penetrance have not yet been fully elucidated. METHODS: We characterized the transcriptomic profiles of circulating...

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PMID: 35978378
DOI: 10.1186/s13024-022-00554-8
PMCID: PMC9386994

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