Article

Regulatory Role of DDX17 in Immune-Autophagy Pathways of Parkinson’s Disease Revealed by Single-Cell and Genetic Analyses

2025-07-21

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) involves dysregulated mitophagy and immune responses, but the underlying mechanisms remain unclear. This study integrated single-cell sequencing (GSE157783) and Mendelian randomization (MR) to identify key mitophagy- and immune-related genes (MRGs/IRGs) in PD. We identified astrocyte and microglia subpopulations, screened differentially expressed genes (DEGs), a...

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Literature Corpus work: adf2851e-b702-597d-904f-ff472e088a75
DOI: 10.21203/rs.3.rs-7047737/v1

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