Article

Integrated Stress Response Signatures Drive Monocyte Dysfunction in GBA1- and LRRK2-Linked Parkinson’s Disease

2026-02-16

Abstract excerpt

<title>Abstract</title> <p> Monocytes are increasingly implicated in Parkinson’s disease (PD) pathogenesis, with idiopathic cases showing mitochondrial and lysosomal dysfunction. However, the impact of PD-associated mutations on monocytes remains unclear. To address this, we investigated transcriptomic and functional disturbances in peripheral monocytes from patients with <italic>GBA1</italic> - and <italic>L...

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Literature Corpus work: b90dc375-22f8-58b5-ae42-4830e48b3cc1
DOI: 10.21203/rs.3.rs-8615050/v1

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