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<i>LRRK2</i> G2019S variant is associated with transcriptional changes in Parkinson’s disease human myeloid cells under proinflammatory environment

2024-06-01

Abstract excerpt

The G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene is a major risk factor for the development of Parkinson’s disease (PD). LRRK2, although ubiquitously expressed, is highly abundant in cells of the innate immune system. Given the importance of central and peripheral immune cells in the development of PD, we sought to investigate the consequences of the G2019S mutation on microglial and monocyte t...

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Literature Corpus work
18596b05-d263-582e-9b94-e1b5f1e229ca
DOI
10.1101/2024.05.27.594821
Open publication

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<i>LRRK2</i> G2019S variant is associated with transcriptional changes in Parkinson’s disease human myeloid cells under proinflammatory environmentDOI 10.1101/2024.05.27.594821
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