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Article

Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.

Molecular and cellular biology - 15 Jan 2016

Saito Ryota, Suzuki Takafumi, Hiramoto Keiichiro, Asami Soichiro, Naganuma Eriko, Suda Hiromi, Iso Tatsuro, Yamamoto Hirotaka, Morita Masanobu, Baird Liam, Furusawa Yuki, Negishi Takaaki, Ichinose Masakazu, Yamamoto Masayuki

Abstract excerpt

The Keap1-Nrf2 system plays a central role in cytoprotection against electrophilic/oxidative stresses. Although Cys151, Cys273, and Cys288 of Keap1 are major sensor cysteine residues for detecting these stresses, it has not been technically feasible to evaluate the functionality of Cys273 or Cys288, since Keap1 mutants that harbor substitutions in these residues and maintain the ability to repress Nrf2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26527616
DOI: 10.1128/MCB.00868-15
PMCID: PMC4719294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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