Article
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds.
Molecular and cellular biology - 1 Jan 2009
Kobayashi Makoto, Li Li, Iwamoto Noriko, Nakajima-Takagi Yaeko, Kaneko Hiroshi, Nakayama Yuko, Eguchi Masami, Wada Yoshiko, Kumagai Yoshito, Yamamoto Masayuki
Abstract excerpt
Animals have evolved defense systems for surviving in a chemically diverse environment. Such systems should demonstrate plasticity, such as adaptive immunity, enabling a response to even unknown chemicals. The antioxidant transcription factor Nrf2 is activated in response to various electrophiles and induces cytoprotective enzymes that detoxify them. We report here the discovery of a multiple sensing mechanism...
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