Article
Finding co-mutated genes and candidate cancer genes in cancer genomes by stratified false discovery rate control.
Molecular bioSystems - 1 Apr 2011
Wang Jing, Zhang Yang, Shen Xiaopei, Zhu Jing, Zhang Lin, Zou Jinfeng, Guo Zheng
Abstract excerpt
Finding candidate cancer genes playing causal roles in carcinogenesis is an important task in cancer research. The non-randomness of the co-mutation of genes in cancer samples can provide statistical evidence for these genes' involvement in carcinogenesis. It can also provide important information on the functional cooperation of gene mutations in cancer. However, due to the relatively small sample sizes used in...
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