Article
Analysis of pathway mutation profiles highlights collaboration between cancer-associated superpathways.
Human mutation - 1 Sept 2011
Gu Yunyan, Zhao Wenyuan, Xia Jiguang, Zhang Yuannv, Wu Ruihong, Wang Chenguang, Guo Zheng
Abstract excerpt
The biological interpretation of the complexity of cancer somatic mutation profiles is a major challenge in current cancer research. It has been suggested that mutations in multiple genes that participate in different pathways are collaborative in conferring growth advantage to tumor cells. Here, we propose a powerful pathway-based approach to study the functional collaboration of gene mutations in...
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