Article

Extracellular K <sup>+</sup> modulates the pore conformations of Cys-loop receptor anion channels

2025-06-17

Abstract excerpt

K + is an essential cation for life, but no eukaryotic membrane protein with a modulatory site for extracellular K + has been discovered. Here, we report that a Cys-loop receptor, CG12344/DmAlka, expressed in the Drosophila nervous system, is selectively modulated by physiological concentration of extracellular K + . Structural prediction, electrophysiology and phylogenetic analysis of DmAlka revealed the extr...

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Literature Corpus work: 4ac2d741-9372-5df2-85a9-ecda88f1897a
DOI: 10.1101/2025.06.15.658987

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