Article

Proton selective conductance and gating of lysosomal cation channel TMEM175

2024-11-03

Abstract excerpt

The lysosomal cation channel TMEM175 is crucial for maintaining lysosomal function and pH homeostasis, and its aberrant function is linked to Parkinson’s disease (PD). While TMEM175 activity was first interpreted in the context of its potassium (K + ) selective conductance, subsequent studies revealed also a substantial permeability to protons (H + ). Here we dissect the complex changes in TMEM175 conductance an...

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Literature Corpus work: 0cee66a3-2bac-58a2-a769-30e6aa472f45
DOI: 10.1101/2024.11.01.621492

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