Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective ion permeation involves complexation with carboxylates and lysine in a model human sodium channel.

PLoS computational biology - 1 Sept 2018

Flood Emelie, Boiteux Céline, Allen Toby W

Abstract excerpt

Bacterial and human voltage-gated sodium channels (Navs) exhibit similar cation selectivity, despite their distinct EEEE and DEKA selectivity filter signature sequences. Recent high-resolution structures for bacterial Navs have allowed us to learn about ion conduction mechanisms in these simpler homo-tetrameric channels, but our understanding of the function of their mammalian counterparts remains limited. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amines
Share to Carboxylic Acids
Share to Ions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Potentials

Share to NAV1.2 Voltage-Gated Sodium Channel

Share to Potassium

Share to Sodium

Share to Static Electricity

Source

Open in PubMed Open full text

Identifiers

PMID: 30208027
DOI: 10.1371/journal.pcbi.1006398
PMCID: PMC6152994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective ion permeation involves complexation with carboxylates and lysine in a model human sodium channel.PMID 30208027Read ↗

Sodium and potassium competition in potassium-selective and non-selective channels.Semantic proximity Read ↗

From Selective Permeation to Physiology in Potassium Channels.Semantic proximity Read ↗

The mechanism of Na⁺/K⁺ selectivity in mammalian voltage-gated sodium channels based on molecular dynamics simulation.Semantic proximity Read ↗

Molecular basis of ion permeability in a voltage-gated sodium channel.Semantic proximity Read ↗

Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium channel.Semantic proximity Read ↗

Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complexSemantic proximity Read ↗

Nonselective conduction in a mutated NaK channel with three cation-binding sites.Semantic proximity Read ↗

Structural and Energetic Basis of Ca2+-Selective Permeation in the TRPV5 Channel.Semantic proximity Read ↗

The voltage-sensing domain of a hERG1 mutant is a cation-selective channel.Semantic proximity Read ↗

Cryo-EM structures of the human sodium-potassium pump revealing the gating mechanism on the cytoplasmic sideSemantic proximity Read ↗

Structure of the light-driven sodium pump KR2 and its implications for optogenetics.Semantic proximity Read ↗

A hydrophobic funnel governs monovalent cation selectivity in the ion channel TRPM5.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.