Article
Survivin prevents the Polycomb Repressor Complex 2 from methylating Histone 3 lysine 27
2022-04-27
Abstract excerpt
Survivin is a small protein that belongs to the inhibitor of apoptosis protein family and participates in cell division and apoptosis. It was actively studied in human cancers, inflammatory diseases and in autoimmune diseases. Here, we reveal that survivin takes part in epigenetic gene silencing by interaction with the polycomb repressive complex 2 (PRC2). PRC2 silences gene expression through tri-methylation of l...
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Identifiers and source
- Literature Corpus work
- de7a8713-6636-5447-a0b2-3b18a3bad534
- DOI
- 10.1101/2022.04.27.489567