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Article

Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription.

Molecular cell - 7 Dec 2017

Ardehali M Behfar, Anselmo Anthony, Cochrane Jesse C, Kundu Sharmistha, Sadreyev Ruslan I, Kingston Robert E

Abstract excerpt

Polycomb repressive complex 2 (PRC2-EZH2) methylates histone H3 at lysine 27 (H3K27) and is required to maintain gene repression during development. Misregulation of PRC2 is linked to a range of neoplastic malignancies, which is believed to involve methylation of H3K27. However, the full spectrum of non-histone substrates of PRC2 that might also contribute to PRC2 function is not known. We characterized the...

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Identifiers

PMID: 29153392
DOI: 10.1016/j.molcel.2017.10.025
PMCID: PMC5800316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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