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Article

Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.

The Journal of biological chemistry - 12 Nov 2010

Wang Haijuan, Holloway Michael P, Ma Li, Cooper Zachary A, Riolo Matthew, Samkari Ayman, Elenitoba-Johnson Kojo S J, Chin Y Eugene, Altura Rachel A

Abstract excerpt

The multiple functions of the oncofetal protein survivin are dependent on its selective expression patterns within immunochemically distinct subcellular pools. The mechanism by which survivin localizes to these compartments, however, is only partly understood. Here we show that nuclear accumulati...

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Source

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Identifiers

PMID: 20826784
DOI: 10.1074/jbc.M110.152777
PMCID: PMC2975235

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20826784-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.PMID 20826784Read ↗

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Stat3 dimerization regulated by reversible acetylation of a single lysine residue.Semantic proximity Read ↗

The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3Semantic proximity Read ↗

Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement.Semantic proximity Read ↗

Survivin: A molecular biomarker in cancer.Semantic proximity Read ↗

The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin.Semantic proximity Read ↗

Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.Semantic proximity Read ↗

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.Semantic proximity Read ↗

Separating the anti-apoptotic and mitotic roles of survivin.Semantic proximity Read ↗

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