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Article

An IAP in Action: The Multiple Roles of Survivin in Differentiation, Immunity and Malignancy

9 Sept 2004

Abstract excerpt

The proteolytic activity of caspases is tightly controlled by the inhibitor of apoptosis protein (IAP) family that has evolved to protect cells from unwanted self-execution by fortuitous activation of the death cascade. Survivin is a 17 kD protein that contains only a single BIR and no RING domain. It stands out for its close association with cancer where its expression correlates with drug resistance and poor...

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PMID: 15326382
DOI: 10.4161/cc.3.9.1093

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