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Article

Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor Types

24 Jun 2021

Abstract excerpt

PRC2 (Polycomb repressive complex 2) is an evolutionarily conserved protein complex required to maintain transcriptional repression. The core PRC2 complex includes EZH2, SUZ12, and EED proteins and methylates histone H3K27. PRC2 is known to contribute to carcinogenesis and several small molecule inhibitors targeting PRC2 have been developed. The present study aimed to identify the cancer types in which PRC2...

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PMID: 34202528
DOI: 10.3390/cancers13133155

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