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Article

Structure of the PRC2 complex and application to drug discovery.

Acta pharmacologica Sinica - 1 Jul 2017

Shi Yi, Wang Xiao-Xi, Zhuang You-Wen, Jiang Yi, Melcher Karsten, Xu H Eric

Abstract excerpt

The polycomb repressive complexes 2 (PRC2) complex catalyzes tri-methylation of histone H3 lysine 27 (H3K27), a repressive chromatin marker associated with gene silencing. Overexpression and mutations of PRC2 are found in a wide variety of cancers, making the catalytic activity of PRC2 an important target of cancer therapy. This review highlights recent structural breakthroughs of the human PRC2 complex bound to...

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Identifiers

PMID: 28414199
DOI: 10.1038/aps.2017.7
PMCID: PMC5519257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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