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SURVIVIN IN SYNERGY WITH BAF/SWI COMPLEX BINDS BIVALENT CHROMATIN REGIONS AND ACTIVATES DNA DAMAGE RESPONSE IN CD4+ T CELLS

2024-03-10

Abstract excerpt

This study explores a regulatory role of oncoprotein survivin on the bivalent regions of chromatin (BvCR) characterized by concomitant deposition of trimethylated lysine of histone H3 at position 4 (H3K4me3) and 27 (H3K27me3). Intersect between BvCR and chromatin sequences bound to survivin demonstrated their co-localization on cis -regulatory elements of genes which execute DNA damage control in primary human CD...

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Literature Corpus work: cd1a2b43-3b84-57a2-9f20-6b17beb5530d
DOI: 10.1101/2024.03.05.583464

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