Article

A Shared Amyloid Architecture in Cardiac Fibrils from Three Neuropathy-Associated ATTR Variants

2025-08-07

Abstract excerpt

<h4>Summary</h4> ATTR amyloidosis results from the systemic accumulation of wild-type (ATTRwt) or mutant (ATTRv) transthyretin amyloids, leading to multi-organ dysfunction and death. The disease exhibits variable pathology and penetrance, and its relationship with the amyloid structure remains unclear. Patients carrying the neuropathy-associated variants ATTRvI84S and ATTRv-V122Δ present polymorphic ATTR fibrils,...

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Literature Corpus work: de577cb0-c860-536e-8e45-e936ac8c8b5e
DOI: 10.1101/2025.08.05.667944

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