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Amyloid fibril polymorphism in the heart and liver of a patient with polyneuropathic ATTRv-V122Δ amyloidosis.

Communications biology - 1 Apr 2026

Ahmed Yasmin, Nguyen Binh An, Kelly Candace, Afrin Shumaila, Singh Virender, Evers Bret M, Shelton John M, Lopez Escobar Christian, Singh Preeti, Pedretti Rose, Wang Lanie, Bassett Parker, Fernandez-Ramirez Maria Del Carmen, Pekala Maja, Lemoff Andrew, Kluve-Beckerman Barbara, Saelices Lorena

Abstract excerpt

ATTR amyloidosis is a phenotypically heterogeneous disease characterized by the pathological deposition of transthyretin in the form of amyloid fibrils into various organs. ATTR amyloidosis may result from mutations in variant (ATTRv) amyloidosis, or aging in wild-type (ATTRwt) amyloidosis. ATTRwt generally manifests as cardiomyopathy, whereas ATTRv may present as polyneuropathy, cardiomyopathy, or mixed, in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41917523
DOI: 10.1038/s42003-026-09919-x
PMCID: PMC13201594

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