Article
A shared amyloid fold in cardiac fibrils from three neuropathy-associated ATTR variants.
Structure (London, England : 1993) - 5 Mar 2026
Fernandez-Ramirez Maria Del Carmen, Afrin Shumaila, Nguyen Binh An, Singh Virender, Pękala Maja, Singh Preeti, Ahmed Yasmin, Pedretti Rose, Lemoff Andrew, Kluve-Beckerman Barbara, Chhapra Farzeen, Eisenberg David, Saelices Lorena
Abstract excerpt
ATTR amyloidosis results from the systemic accumulation of wild-type (ATTRwt) or mutant (ATTRv) transthyretin amyloids, leading to multi-organ dysfunction and death. The disease exhibits variable pathology and penetrance, and its relationship with the amyloid structure remains unclear. Patients carrying the neuropathy-associated variants ATTRvI84S and ATTRv-V122Δ present polymorphic ATTR fibrils, in contrast to...
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