Article

Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis

2024-03-09

Abstract excerpt

ATTR amyloidosis results from the conversion of transthyretin into amyloid fibrils that deposit in tissues causing organ failure and death. This conversion is facilitated by mutations in ATTRv amyloidosis, or aging in ATTRwt amyloidosis. ATTRv amyloidosis exhibits extreme phenotypic variability, whereas ATTRwt amyloidosis presentation is consistent and predictable. Previously, we found an unprecedented structural...

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Literature Corpus work: 9904c144-3462-5e5b-bf94-457028f9c78b
DOI: 10.1101/2024.03.08.582936

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