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Article

Structural and molecular homogeneity of ATTRv-T60A amyloid fibrils across patients and organs.

Structure (London, England : 1993) - 4 Dec 2025

Fernandez-Ramirez Maria Del Carmen, Nguyen Binh A, Afrin Shumaila, Singh Virender, Evers Bret, Shelton John M, Escobar Christian Lopez, Bassett Parker, Wang Lanie, Pękała Maja, Ahmed Yasmin, Cabrera Hernandez Luis O, Pedretti Rose, Singh Preeti, Canepa Jacob, Wosztyl Aleksandra, Li Yang, Boyer David R, Cao Qin, Saelices Lorena

Abstract excerpt

Transthyretin amyloidosis is a systemic protein misfolding disorder with diverse clinical phenotypes, including cardiomyopathy, polyneuropathy, or a combination of both. While structural polymorphism of amyloid fibrils has been linked to disease heterogeneity in neurodegenerative disorders, its role in transthyretin amyloidosis remains unclear. Here, we used cryo-electron microscopy to analyze ex vivo fibrils...

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Identifiers

PMID: 41106377
DOI: 10.1016/j.str.2025.09.008
PMCID: PMC12616452

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