Article

Structure of ATTRv-F64S fibrils isolated from skin tissue of a living patient

2025-07-30

Abstract excerpt

Amyloid transthyretin-derived (ATTR) amyloidosis is a degenerative, systemic disease characterized by transthyretin fibril deposition in organs like the heart, kidneys, liver, and skin. We report the first cryo-EM structure of transthyretin fibrils isolated from skin tissue of a living patient carrying a rare genetic mutation (ATTRv F64S). The structure adopts a highly conserved fold previously observed in other A...

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Literature Corpus work: b38c4d40-b597-5eac-9fdf-19f1b9cf8c93
DOI: 10.1101/2025.07.29.667442

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