Article

Structural polymorphism of amyloid fibrils in cardiac transthyretin amyloidosis revealed by cryo-electron microscopy

2022-06-21

Abstract excerpt

The deposition of amyloidogenic transthyretin (ATTR) in ATTR amyloidosis leads to an unexplained variety of clinical phenotypes, including cardiomyopathy. In brain amyloid conditions, there is an apparent association between the clinical phenotype and the amyloid fibril structure. Here, we question this phenotype-structure association in cardiac amyloidoses by determining the cryo-electron microscopy structures of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b8902bb4-39eb-5a5e-89b7-4f6192683457
DOI: 10.1101/2022.06.21.496949

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural polymorphism of amyloid fibrils in cardiac transthyretin amyloidosis revealed by cryo-electron microscopyDOI 10.1101/2022.06.21.496949Read

Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosisSemantic proximity Read

Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis.Semantic proximity Read

Transthyretin amyloid fibrils adopt distinct folds in the brainSemantic proximity Read

ATTRv-V30M Type A amyloid fibrils from heart and nerves exhibit structural homogeneitySemantic proximity Read

A Shared Amyloid Architecture in Cardiac Fibrils from Three Neuropathy-Associated ATTR VariantsSemantic proximity Read

A shared amyloid fold in cardiac fibrils from three neuropathy-associated ATTR variants.Semantic proximity Read

Amyloid fibril polymorphism in the heart and liver of an ATTR amyloidosis patient with polyneuropathy attributed to the ATTRv-V122Δ variantSemantic proximity Read

Multi-organ structural homogeneity of amyloid fibrils in ATTRv-T60A amyloidosis patients, revealed by Cryo-EMSemantic proximity Read

Structure of ATTRv-F64S fibrils isolated from skin tissue of a living patientSemantic proximity Read

Structure-based probe reveals the presence of large transthyretin aggregates in plasma of ATTR amyloidosis patientsSemantic proximity Read

Structural and molecular homogeneity of ATTRv-T60A amyloid fibrils across patients and organs.Semantic proximity Read

Amyloid fibril polymorphism in the heart and liver of a patient with polyneuropathic ATTRv-V122Δ amyloidosis.Semantic proximity Read