Article

Amyloid fibril polymorphism in the heart and liver of an ATTR amyloidosis patient with polyneuropathy attributed to the ATTRv-V122Δ variant

2024-05-10

Abstract excerpt

ATTR amyloidosis is a phenotypically heterogeneous disease characterized by the pathological deposition of transthyretin in the form of amyloid fibrils into various organs. ATTR amyloidosis may result from mutations in variant (ATTRv) amyloidosis, or aging in wild-type (ATTRwt) amyloidosis. ATTRwt generally manifests as cardiomyopathy, whereas ATTRv may present as polyneuropathy, cardiomyopathy, or mixed, in combi...

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Literature Corpus work: 0c0152cc-a650-5f76-b9da-b0d3102c2110
DOI: 10.1101/2024.05.09.593396

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