Article
Cryo-EM structures of biopsy-derived TTR fibrils in hereditary transthyretin amyloidosis.
Nature communications - 24 Jul 2026
Zheng Yuxin, Liang Jiawei, Li Zhenyu, Liu Yixiao, Chu Xujun, Zhang Shaochong, Wang Wenjuan, Bao Jionglin, Liu Boyu, Ma Conghui, Yin Guowei, Deng Jianwen, Chi Wei, Meng Lingchao, Shi Yang
Abstract excerpt
Hereditary transthyretin amyloidosis (ATTRv) is a fatal autosomal dominant disease characterized by systemic deposition of transthyretin (TTR) amyloid fibrils, leading to progressive neuropathy and cardiomyopathy. More than 130 pathogenic mutations in the TTR gene have been identified, but their roles in TTR fibril formation and disease pathogenesis remain unclear. Here, using cryo-electron microscopy (cryo-EM),...
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