Article

Transthyretin amyloid fibrils adopt distinct folds in the brain

2026-05-14

Abstract excerpt

Amyloid deposition in the central nervous system is increasingly recognized in transthyretin (ATTR) amyloidosis, particularly in patients with prolonged survival following liver transplantation or disease-modifying therapies. However, the structural basis of transthyretin aggregation in the brain remains unknown. Here we determine cryo-electron microscopy (cryo-EM) structures of ex vivo brain-derived ATTR fibrils...

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Literature Corpus work: 8d22b0fb-3fa4-5ab8-ade8-a38f12c23b35
DOI: 10.64898/2026.05.12.724695

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