Article

ATTRv-V30M Type A amyloid fibrils from heart and nerves exhibit structural homogeneity

2024-05-14

Abstract excerpt

ATTR amyloidosis is a systemic disease characterized by the deposition of amyloid fibrils made of transthyretin, a protein integral to transporting retinol and thyroid hormones. Transthyretin is primarily produced by the liver and circulates in blood as a tetramer. The retinal epithelium also secretes transthyretin, which is secreted to the vitreous humor of the eye. Because of mutations or aging, transthyretin ca...

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Literature Corpus work: d22dc12d-6b69-5e9c-ab0f-2bd96806f80f
DOI: 10.1101/2024.05.14.594028

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