An <i>APOE</i> *4-Informed Genomic Atlas of the X Chromosome in Alzheimer’s Disease

Abstract excerpt

The genetic contributions of the X chromosome to Alzheimer’s disease (AD) remain poorly understood yet are expected to importantly shape sex differences in AD. We therefore performed large-scale X-chromosome-wide association studies (N=1,240,451), evaluating differential risk due to sex, APOE *4, and escape from X-chromosome inactivation, finding most X-linked loci appear relevant to female-biased AD etiology. In...

Topics

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• Aged
• Aged, 80 and over
• Alzheimer Disease
• Case-Control Studies
• Chromosomes, Human, X
• Genetic Association Studies
• Genetic Predisposition to Disease
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

de2cbacb-5b3b-5954-9170-2efa7fcc228b

DOI

10.64898/2026.05.05.26352461