Article
Role of the X Chromosome in Alzheimer Disease Genetics.
JAMA neurology - 1 Oct 2024
Belloy Michael E, Le Guen Yann, Stewart Ilaria, Williams Kennedy, Herz Joachim, Sherva Richard, Zhang Rui, Merritt Victoria, Panizzon Matthew S, Hauger Richard L, Gaziano J Michael, Logue Mark, Napolioni Valerio, Greicius Michael D
Abstract excerpt
Importance: The X chromosome has remained enigmatic in Alzheimer disease (AD), yet it makes up 5% of the genome and carries a high proportion of genes expressed in the brain, making it particularly appealing as a potential source of unexplored genetic variation in AD. Objectives: To perform the first large-scale X chromosome-wide association study (XWAS) of AD. Design, Setting, and Participants: This was a...
Topics
- Female
- Humans
- Male
- Alzheimer Disease
- Case-Control Studies
- Chromosomes, Human, X
- Genetic Predisposition to Disease
- Polymorphism, Single Nucleotide
- Genetic Association Studies