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Article

Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease

23 Aug 2021

Abstract excerpt

Importance: The X chromosome represents 5% of the human genome in women and men, and its influence on cognitive aging and Alzheimer disease (AD) is largely unknown. Objective: To determine whether the X chromosome is associated with sex-specific cognitive change and tau pathology in aging and AD. Design, Setting, Participants: This study examined differential gene expression profiling of the X chromosome from an...

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PMID: 34424272
DOI: 10.1001/jamaneurol.2021.2806

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