Article

Sex-specific Associations of Gene Expression with Alzheimer’s Disease Neuropathology and Ante-mortem Cognitive Performance

2025-01-02

Abstract excerpt

The biological mechanisms underlying women’s increased Alzheimer’s disease (AD) prevalence remain undefined. Previous case/control studies have identified sex-biased molecular pathways, but sex-specific relationships between gene expression and AD endophenotypes, particularly sex chromosomes, are underexplored. With bulk transcriptomic data across 3 brain regions from 767 decedents, we investigated sex-specific as...

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Literature Corpus work: 8adfd343-331b-57aa-8c80-b4ac71385af3
DOI: 10.1101/2025.01.02.631098

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