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Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer's disease in a European population.

Translational psychiatry - 4 Sept 2024

Simmonds Emily, Leonenko Ganna, Yaman Umran, Bellou Eftychia, Myers Amanda, Morgan Kevin, Brookes Keeley, Hardy John, Salih Dervis, Escott-Price Valentina

Abstract excerpt

Although there are several genome-wide association studies available which highlight genetic variants associated with Alzheimer's disease (AD), often the X chromosome is excluded from the analysis. We conducted an X-chromosome-wide association study (XWAS) in three independent studies with a pathologically confirmed phenotype (total 1970 cases and 1113 controls). The XWAS was performed in males and females...

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Identifiers

PMID: 39231932
DOI: 10.1038/s41398-024-03058-9
PMCID: PMC11375158

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