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Article

Extreme downregulation of chromosome Y and Alzheimer's disease in men.

Neurobiology of aging - 1 Jun 2020

Caceres Alejandro, Jene Aina, Esko Tonu, Perez-Jurado Luis A, Gonzalez Juan R

Abstract excerpt

Research has revealed scarcely any biological factors of Alzheimer's disease (AD) that are specific to men. Here, we found that the extreme downregulation of chromosome Y (EDY) increases the age-related risk of AD in men. We considered that EDY was a possible male-specific pathway toward AD because EDY is the most likely consequence of the mosaic loss of chromosome Y, which has been recently associated with AD....

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PMID: 32147245
DOI: 10.1016/j.neurobiolaging.2020.02.003

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