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Neuroimaging-derived brain endophenotypes link molecular mechanisms to Alzheimer’s disease and aging

2025-11-27

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) genome-wide association studies (GWAS), typically based on clinical phenotypes, have identified numerous risk loci, yet linking these variants to brain changes and molecular processes remains challenging. We developed a DNE-xQTL framework integrating deep learning-derived dimensional neuroimaging endophenotypes (DNEs) with comprehensive brain molecular quantitative trait...

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Literature Corpus work
56d0a7f8-41bc-59dd-9cc0-746036ee8238
DOI
10.1101/2025.11.25.25340884
Open publication

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Neuroimaging-derived brain endophenotypes link molecular mechanisms to Alzheimer’s disease and agingDOI 10.1101/2025.11.25.25340884
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