Sex-specific Associations of Gene Expression with Alzheimer’s Disease Neuropathology and Ante-mortem Cognitive Performance

Abstract excerpt

<title>Abstract</title> <p> The biological mechanisms underlying the increased prevalence of Alzheimer’s disease (AD) in women remain undefined. While previous case/control studies have identified sex-biased molecular pathways, the sex-specific relationships between gene expression and AD endophenotypes, particularly involving sex chromosomes, are underexplored. With bulk transcriptomic data across 3 brain regio...

Topics

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• Alzheimer Disease
• Apolipoproteins E
• Brain
• Gene Expression Profiling
• Sex Characteristics
• Single-Cell Analysis
• Single-Cell Gene Expression Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

e16b14f8-1371-589a-b657-d24224583d49

DOI

10.21203/rs.3.rs-5938205/v1